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phenobarbital will lower the level or outcome of pimozide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.phenobarbital will reduce the extent or result of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Women of all ages mustn't choose estradiol valer